(2019) Science and education, 3, 31-36. Odessa.

Valery Linnikov,
Doctor of Medicine, professor,
Department of Biology and Health,
The State institution «South Ukrainian National Pedagogical University
named after K. D. Ushynsky»,
26, Staroportofrankivska Str., Odesa, Ukraine,
Saint Paul German Medical and Diagnostic Center,
68/2, Novoselskogo Str., Odesa, Ukraine
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Svyatoslav Linnikov,
lecturer,
Department of Biology and Health
The State institution «South Ukrainian National Pedagogical University
named after K.D. Ushynsky»,
26, Staroportofrankivska Str., Odesa, Ukraine,

TROMBOPHILIA AS THE MAIN LINK OF PATHOGENESIS OF COMPLICATIONS
IN OBSTETRICS AND GYNECOLOGY

The analysis of gemostasiologikal researches on hidden got and genetic forms of trombophilia at women with the burdened anamnesis of syndrome of loss of a fetus. For certain established (p<0,05), that got thrombophilia, conditioned by the AFS at patients with FLS average - 28,6 % cases. The genetic mutation FVLeiden more frequent took place at patients with late abortions (14,3 %), the mutation of prothrombin gene G20210A met for certain rarer in all groups of reproduction losses - 4,8 %. The most widespread appeared the mutation МTHFR C677T - (45,2 %). Factor of potential action of the AFA is genetic thrombophilia: AFS and MTHFR C677T at FLS in 17,4 %, AFS and FV Leiden at FLS at 9,6 %. Patogenetically grounded hidden got end genetic thrombophilia, syndrome of loss of fetus, thromboprophylaxis at these obstetric complications of LMWH - by сleхanе, begun with a fertile cycle and on the stage of invasion of throphoblasta, in absolute most cases (92 – 96 %) considerably improves the end of pregnancy.

 antiphospholipid syndrome, fetal loss syndrome, acquired and genetic thrombophilia, low-molecular weight heparin.

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